Process Pathway Inference via Time Series Analysis

Motivated by recent experimental developments in functional genomics, we construct and test a numerical technique for inferring process pathways, in which one process calls another process, from time series data. We validate using a case in which data are readily available and we formulate an extension, appropriate for genetic regulatory networks, which exploits Bayesian inference and in which the present-day undersampling is compensated for by prior understanding of genetic regulation. KEY WORDS—Genomics, pathways, gene expression regulation, Bayesian statistics, auto-regressive models